Launched in 2018, the All of Us Research Program is an NIH longitudinal cohort study aimed at advancing precision medicine and improving human health by partnering with more than one million US participants. To provide rich opportunities for researchers in all career stages, the All of Us program is building a unique biomedical dataset of expansive health data from diverse populations, particularly those underrepresented in biomedical research.
What kind of data is available? Data from the All of Us Research Program includes electronic health records (EHRs), biospecimens, participant surveys (including social determinants of health), genomics, physical measurements, and mobile/wearable tech. There are currently 804,000+ participants with ~45% being racial and ethnic minorities and more than 80% underrepresented in biomedical research. The dataset includes 440,000+ EHRs and 568,000+ biosamples.
Who is the data available to? The All of Us Research Hub has a 3-tiered data access model.
- Public Tier data provides summary statistics/aggregate data with identifiers removed and is available through Data Snapshots and the Public Data Browser.
- Registered Tier data includes individual-level data that has been transformed to protect patient privacy and is only available to approved researchers on the Researcher Workbench.
- Controlled Tier data provides approved researchers with an institutional Data Use and Registration Agreement access via the Researcher Workbench to additional individual-level data including whole genome sequences and genotyping arrays.
How does this work? The Researcher Workbench is a cloud-based platform for registered researchers to access and analyze Registered and Controlled Tier data using provided tools such as Jupyter Notebook, RStudio, and SAS Studio. All of Us uses a Passport Access Model where authorized users receive a data passport that lets them create workspaces and conduct research. No separate IRB approval is needed. Duke University has a Data Use Agreement with the All of Us Research Program allowing Duke researchers to apply for Registered and Controlled Tier Access.
If you are interested in applying for Researcher Workbench access, please connect to the the Register page for information on the steps you will need to complete.
You can also check out the Research Projects Directory to learn more about how the All of Us dataset is being used by registered researchers. There are currently more than 11,860 active projects in the directory.
For more information, please see the All of Us Research Hub and the Researcher FAQs.